Surgery and radiotherapy are the standard treatment options for patients with squamous cell
carcinoma of the head and neck (SCCHN). Chemotherapy and chemoradiotherapy are new
alternatives for locally advanced disease, particularly induction chemotherapy for patients
with unresectable tumors. In recurrent/metastatic disease and after progression to platin-
based regimens, no treatments other than best supportive care are currently available. Most
SCCHN tumors overexpress the epidermal growth factor receptor (EGFR). This is a tyrosine …